Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410661 | 0.86 | SLC6A1 (0.48) | ITGB3ITGA2BHRH3 | |
| Hydrochloric Acid SCHEMBL8407181 | 0.85 | THRA (0.54) | HTR2AHTR2CHTR7HTR6HRH3 | |
| SCHEMBL8410297 | 0.81 | ITGB3 (0.52) | ITGB3ITGA2BHRH3LTA4H | |
| SCHEMBL8491424 | 0.80 | HTR2A (0.57) | HTR2AHTR2CHTR7HTR6HRH3 | |
| Hydrochloric Acid SCHEMBL8407670 | 0.79 | L3MBTL1 (0.61) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL1519356 | 0.78 | HTR2A (0.75) | HTR2ALTA4HOPRM1 | |
| SCHEMBL18117071 | 0.77 | KCNH2 (0.59) | HTR2AHTR2CHTR7HTR6HRH3 | |
| SCHEMBL4227924 | 0.77 | HTR2A (0.74) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL15566801 | 0.77 | HTR2A (0.57) | HTR2AHTR2CHTR7HTR6HRH3 | |
| SCHEMBL8407585 | 0.77 | CHRNB2 (0.49) | ITGB3ITGA2BHRH3LTA4HF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |