Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410489 | 0.83 | NR1H4 (0.56) | NR1H4KDM4EHPGDALDH1A1HTT | |
| SCHEMBL10788983 | 0.82 | HPGD (0.49) | KEAP1KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1649572 | 0.82 | CHRNB2 (0.68) | KEAP1ALDH1A1HTTCHRNB2CHRNA4 | |
| SCHEMBL436284 | 0.81 | KEAP1 (0.57) | KEAP1ALDH1A1HTTCHRNB2CHRNA4 | |
| SCHEMBL4831306 | 0.79 | NR1H4 (0.56) | NR1H4KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30394743 | 0.79 | HNF4A (0.58) | NR1H4KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4632581 | 0.79 | HNF4A (0.58) | NR1H4KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL27890118 | 0.79 | NR1H4 (0.56) | NR1H4KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL17799595 | 0.77 | HNF4A (0.56) | NR1H4KDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL27450922 | 0.77 | KEAP1 (0.66) | KEAP1KDM4EALDH1A1HTTCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |