Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.51 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437167 | 0.87 | PDCD1 (0.49) | KEAP1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1649572 | 0.85 | CHRNB2 (0.68) | KEAP1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30402499 | 0.83 | SUCNR1 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SUCNR1 | |
| SCHEMBL28254835 | 0.83 | SUCNR1 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SUCNR1 | |
| SCHEMBL8410787 | 0.81 | NR1H4 (0.62) | KEAP1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL450242 | 0.81 | PPARG (0.59) | PDCD1CD274LMNAHTTPPARG | |
| SCHEMBL29256186 | 0.81 | HDAC7 (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3SUCNR1 | |
| SCHEMBL27450922 | 0.80 | KEAP1 (0.66) | KEAP1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL11713322 | 0.78 | KEAP1 (0.56) | KEAP1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL15630971 | 0.78 | KEAP1 (0.49) | KEAP1EGLN1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716326-B2 | Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2014-05-06 | — | — | US | disclosed |
| US-20120065396-A1 | ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065396-A1 | ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME | PPIP5K2, SOST, ALPL | KEAP1 4243/4885CHRNB2 4752/4885CHRNA4 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.