Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 15/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12569762 | 1.00 | OPRD1 (0.62) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL1932152 | 0.92 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL12360008 | 0.92 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL12569769 | 0.90 | OPRD1 (0.60) | OPRD1OPRM1OPRK1 | |
| SCHEMBL231375 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL4825406 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL15764535 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL9925784 | 0.86 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL14108184 | 0.85 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL12569760 | 0.85 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| US-7960389-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |
| US-20100168130-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168130-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| CN-100415729-C | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| US-20070254890-A1 | 4(Phenyl-Piperazinyl-Methyl) Benzamide Derivatives and Their Use for the Treatment of Pain or Gastrointestinal Disorders | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | US | disclosed |
| US-20070249619-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249619-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-7253173-B2 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-08-07 | — | — | US | disclosed |
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-06-08 | — | — | US | disclosed |
| CN-1711252-A | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | OPRK1, TRPV1, OPRM1 | OPRD1 5/4885OPRM1 3/4885OPRK1 1/4885 |
| US-20070254890-A1 | 4(Phenyl-Piperazinyl-Methyl) Benzamide Derivatives and Their Use for the Treatment of Pain or Gastrointestinal Disorders | TRPV1, OPRM1, OPRK1 | OPRD1 6/4885OPRM1 2/4885OPRK1 3/4885 |
| US-20070249619-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20100168130-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.