SCHEMBL8413865

SCHEMBL8413865

C[Si](C)(c1ccc(C(=O)Cl)cc1)c1ccc(C(=O)Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.64
ALDH1A1 P00352 5/20 0.43
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
NAPRT Q6XQN6 1/20 0.34
NR1H2 P55055 1/20 0.34
NR1H3 Q13133 1/20 0.34
ACHE P22303 1/20 0.32
CES2 O00748 3/20 0.32
CES1 P23141 3/20 0.32
LMNA P02545 1/20 0.32
TSHR P16473 4/20 0.32
TP53 P04637 2/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
ALOX15 P16050 1/20 0.31
MAOA P21397 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9716978 0.86 HPGD (0.46) HPGDALDH1A1NAPRTNR1H2NR1H3
SCHEMBL10789745 0.84 HPGD (0.45) HPGDALDH1A1NAPRTACHECES2
SCHEMBL9331875 0.84 HPGD (0.45) HPGDALDH1A1NAPRTACHECES2
SCHEMBL9176742 0.80 HPGD (0.42) HPGDALDH1A1NAPRTACHECES2
SCHEMBL68148 0.79 ALDH1A1 (0.59) HPGDALDH1A1ESR1ESR2NAPRT
SCHEMBL20587670 0.79 ALDH1A1 (0.59) HPGDALDH1A1ESR1ESR2NAPRT
SCHEMBL3482898 0.78 HPGD (1.00) HPGDALDH1A1ESR1ESR2NAPRT
SCHEMBL10788786 0.78 ALDH1A1 (0.45) HPGDALDH1A1NAPRTCES2CES1
SCHEMBL11355232 0.77 NR1H2 (0.47) HPGDALDH1A1NR1H2NR1H3
SCHEMBL28300029 0.76 HPGD (0.64) HPGDALDH1A1TSHRSMN1; SMN2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0291778-A1 Process for the preparation of high temperature-resistant dielectrics SIEMENS AKTIENGESELLSCHAFT (DE) 1988-11-23 EP claimed
CN-108601460-B Vehicle seat member, vehicle seat, and method for manufacturing same 积水化成品工业株式会社 2021-02-05 CN disclosed
US-5955209-A Thin-film electroluminescent device MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1999-09-21 US disclosed
US-5820992-A SEMIPERMEABLE MEMBRANE; GAS SEPARATION; AROMATIC POLYESTER NATIONAL CHEMICAL LABORATORY (IN) 1998-10-13 US disclosed
EP-0622975-B1 Thin-film electroluminescent device MITSUI PETROCHEMICAL IND (JP) 1997-11-05 EP disclosed
US-5627255-A ENGINEERING THERMOPLASTICS TO BE USED IN PLACE OF METALS OR GLASS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 1997-05-06 US disclosed
US-5606000-A BISPHENOL-TYPE MONOMER AND A DICARBOXY-DIPHENYLSILANE MONOMER; SEMIPERMEABLE MEMBRANE NATIONAL CHEMICAL LABORATORY (IN) 1997-02-25 US disclosed
EP-0622975-A1 Thin-film electroluminescent device MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-02 EP disclosed
US-4965134-A Method for manufacturing highly heat-resistant dielectrics SIEMENS AKTIENGESELLSCHAFT (DE) 1990-10-23 US disclosed
EP-0373834-A2 Hydrogenated diene copolymer-containing resin composition and process for producing the same JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1990-06-20 EP disclosed
US-4839425-A MOLDING MATERIALS; IMPACT STRENGTH, HEAT RESISTANCE JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1989-06-13 US disclosed
EP-0291778-A1 Process for the preparation of high temperature-resistant dielectrics SIEMENS AKTIENGESELLSCHAFT (DE) 1988-11-23 EP disclosed