SCHEMBL8416306

SCHEMBL8416306

c1ccc(-c2nccn2CCCCN2CCN(c3ncccn3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 7/20 0.53
ALDH1A1 P00352 2/20 0.51
TSHR P16473 1/20 0.51
DRD3 P35462 5/20 0.50
DRD2 P14416 4/20 0.50
HTR2A P28223 4/20 0.50
DRD1 P21728 2/20 0.50
DRD5 P21918 1/20 0.50
P2RX7 Q99572 1/20 0.49
ESR1 P03372 1/20 0.49
SLC6A2 P23975 1/20 0.48
DRD4 P21917 2/20 0.47
HTR7 P34969 2/20 0.47
KDM1A O60341 1/20 0.47
ABCB11 O95342 1/20 0.46
CYP1A2 P05177 1/20 0.46
ADRA2A P08913 1/20 0.46
CYP2D6 P10635 1/20 0.46
ADRA2B P18089 1/20 0.46
ADRA2C P18825 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7095574 0.82 ESR1 (0.68) ALDH1A1TSHRP2RX7ESR1CYP2C19
SCHEMBL8419622 0.81 P2RX7 (0.60) HTR1AALDH1A1DRD3DRD2HTR2A
SCHEMBL8419683 0.78 PRKD3 (0.54) HTR1AALDH1A1TSHRDRD3DRD2
SCHEMBL8419620 0.77 HTR1A (0.51) HTR1ADRD3DRD2HTR2ADRD1
SCHEMBL26492991 0.77 HTR1A (0.65) HTR1AALDH1A1DRD3DRD2HTR2A
SCHEMBL26108581 0.77 HTR1A (0.65) HTR1AALDH1A1DRD3DRD2HTR2A
SCHEMBL5847869 0.77 SIGMAR1 (0.54) ALDH1A1DRD2P2RX7ESR1
SCHEMBL462620 0.76 ESR1 (0.60) ALDH1A1TSHRP2RX7ESR1CYP2C19
SCHEMBL5846853 0.76 SIGMAR1 (0.59) HTR1ADRD3DRD2ESR1DRD4
Hydrochloric Acid SCHEMBL5847600 0.76 MAOA (0.50) TSHRP2RX7ESR1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0655248-B1 Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion ESTEVE LABOR DR (ES) 1999-09-15 EP claimed
EP-0808166-A1 MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1997-11-26 EP claimed
WO-1997021439-A1 MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1997-06-19 WO claimed
US-5532234-A Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion LABORATORIES DEL DR. ESTEVE, S.A. (ES) 1996-07-02 US claimed
EP-0502786-B1 Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives ESTEVE LABOR DR (ES) 1996-04-24 EP claimed
EP-0655248-A1 Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1995-05-31 EP claimed
EP-0502786-A1 Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1992-09-09 EP claimed
EP-0808166-A1 MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1997-11-26 EP disclosed
WO-1997021439-A1 MEDICAMENT INTENDED TO THE TREATMENT OF OBSESSIVE COMPULSIVE TROUBLES, SLEEP APNOEA, SEXUAL DYSFUNCTIONS, EMESA AND TRANSPORT SICKNESS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1997-06-19 WO disclosed