SCHEMBL5847869

SCHEMBL5847869

OC1(c2ccccc2)CCN(CCCCn2ccnc2-c2ccccc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.54
DRD2 P14416 2/20 0.50
ESR1 P03372 1/20 0.49
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 1/20 0.48
LMNA P02545 1/20 0.48
KMT2A Q03164 1/20 0.48
CCR3 P51677 1/20 0.48
OPRL1 P41146 2/20 0.48
KCNA3 P22001 1/20 0.46
CCR1 P32246 2/20 0.45
POLB P06746 1/20 0.45
P2RX7 Q99572 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7095574 0.79 ESR1 (0.68) ESR1ALDH1A1KMT2APOLBP2RX7
SCHEMBL5847870 0.78 SIGMAR1 (0.53) SIGMAR1DRD2MEN1ALDH1A1LMNA
SCHEMBL8416306 0.77 HTR1A (0.53) DRD2ESR1ALDH1A1P2RX7
Hydrochloric Acid SCHEMBL5847600 0.76 MAOA (0.50) SIGMAR1ESR1P2RX7
SCHEMBL5846990 0.75 SIGMAR1 (0.59) SIGMAR1DRD2MEN1ALDH1A1LMNA
SCHEMBL11062805 0.75 SIGMAR1 (0.70) SIGMAR1DRD2MEN1ALDH1A1LMNA
SCHEMBL5847565 0.75 DRD2 (0.59) SIGMAR1DRD2MEN1ALDH1A1LMNA
SCHEMBL5848627 0.74 SIGMAR1 (0.58) SIGMAR1DRD2MEN1ALDH1A1LMNA
SCHEMBL5847529 0.74 SIGMAR1 (0.58) SIGMAR1DRD2MEN1ALDH1A1LMNA
Hydrochloric Acid SCHEMBL11073893 0.74 SIGMAR1 (0.68) SIGMAR1DRD2MEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
CN-1166173-A Tetrahydropyridine- (or 4-hydroxypiperidine) alkylpyrroles active at sigma and/or 5HTIA receptors ESTEVE S A LAB DE DR (ES) 1997-11-26 CN claimed