Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 5/20 | 0.41 |
| ▸ | GALR2 | O43603 | 2/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823458 | 0.85 | HTR6 (0.68) | HTR6MAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL8416375 | 0.85 | GAA (0.37) | MAPTALDH1A1KMOGALR2RECQL | |
| SCHEMBL7823536 | 0.83 | HTR6 (0.68) | HTR6MAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7836309 | 0.81 | GFER (0.58) | MAPTALDH1A1KDM4EMEN1GAA | |
| SCHEMBL7832160 | 0.71 | L3MBTL1 (0.53) | HTR6MAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL8413208 | 0.69 | HTR6 (0.54) | HTR6MAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7838498 | 0.68 | GFER (0.57) | MAPTALDH1A1KDM4ENPSR1MEN1 | |
| SCHEMBL7833289 | 0.68 | LMNA (0.50) | HTR6MAPTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL11757838 | 0.68 | PDE4A (0.69) | ALDH1A1KDM4EHSD11B1MEN1KMT2A | |
| SCHEMBL9217636 | 0.68 | NUDT1 (0.68) | MAPTALDH1A1KDM4EBLMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |