Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KMO | O15229 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GALR2 | O43603 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416384 | 0.85 | HTR6 (0.48) | GAAKMOMAPTKMT2AALDH1A1 | |
| SCHEMBL7833289 | 0.83 | LMNA (0.50) | GAAL3MBTL1MAPTTDP1LMNA | |
| SCHEMBL7838498 | 0.80 | GFER (0.57) | GAAL3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL8413419 | 0.77 | HTR6 (0.51) | GAAMAPTKMT2ATDP1LMNA | |
| SCHEMBL8413208 | 0.74 | HTR6 (0.54) | GAAL3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL8416374 | 0.72 | L3MBTL1 (0.48) | GAAL3MBTL1MAPTKMT2AALDH1A1 | |
| SCHEMBL8413230 | 0.71 | CES1 (0.44) | GAAKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL7823458 | 0.71 | HTR6 (0.68) | L3MBTL1KMOMAPTTDP1LMNA | |
| SCHEMBL7823536 | 0.68 | HTR6 (0.68) | L3MBTL1MAPTTDP1LMNAALDH1A1 | |
| SCHEMBL1697668 | 0.68 | CASP1 (0.48) | MAPTKMT2ATDP1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |