SCHEMBL8417246

SCHEMBL8417246

Clc1cccc(N=C=Nc2cccc(Cl)c2Cl)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100B P04271 1/20 0.46
ITGB3 P05106 1/20 0.46
ITGAV P06756 1/20 0.46
TSHR P16473 3/20 0.41
HTR3E A5X5Y0 1/20 0.40
HTR3B O95264 1/20 0.40
HTR3A P46098 1/20 0.40
HTR3D Q70Z44 1/20 0.40
HTR3C Q8WXA8 1/20 0.40
PNMT P11086 2/20 0.38
GALR3 O60755 1/20 0.38
CYP1A2 P05177 2/20 0.36
CYP2A6 P11509 1/20 0.36
LMNA P02545 2/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
NFKB1 P19838 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
DRD2 P14416 2/20 0.34
DRD3 P35462 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9741930 0.82 S100B (0.43) S100BITGB3ITGAVTSHRHTR3E
SCHEMBL29668094 0.82 ALDH1A1 (0.48) S100BITGB3ITGAVTSHRHTR3E
SCHEMBL895789 0.82 ALDH1A1 (0.48) S100BITGB3ITGAVTSHRHTR3E
SCHEMBL93182 0.82 CYP3A4 (0.54) S100BITGB3ITGAVTSHRHTR3E
SCHEMBL29862583 0.82 CYP3A4 (0.54) S100BITGB3ITGAVTSHRHTR3E
Ammonia Solution, Strong SCHEMBL28180433 0.80 CYP3A4 (0.52) S100BITGB3ITGAVTSHRHTR3E
SCHEMBL29529229 0.80 HTR3E (0.54) TSHRHTR3EHTR3BHTR3AHTR3D
SCHEMBL444165 0.80 HTR3E (0.54) TSHRHTR3EHTR3BHTR3AHTR3D
SCHEMBL9742778 0.78 MAPK1 (0.39) CYP2A6CYP3A4
SCHEMBL3304879 0.78 S100B (0.47) S100BITGB3ITGAVTSHRHTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5866672-A HALOGEN FLAME RETARDANT, EPOXY COMPOUNDS OR CARBODIIMIDE COMPOUNDS AND AN ANTIMONY COMPOUND KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1999-02-02 US disclosed
EP-0763567-A1 FLAME-RETARDANT POLYETHYLENE TEREPHTHALATE RESIN COMPOSITIONS Kanegafuchi Kagaku Kogyo Kabushiki Kaisha (JP) 1997-03-19 EP disclosed
US-5084304-A Heat resistant coating applied to a metal, a heat resistant material polymer such as a blend of a polyesterimide, a polyhydantoin, a polyamide, a polyamideimide copolymer and a polybismaleimide BASF LACKE & FARBEN AG (DE) 1992-01-28 US disclosed
US-4166067-A PROCESS FOR THE PREPARATION OF ALKOXYMETHYL-ISOCYANATES BAYER AKTIENGESELLSCHAFT (DE) 1979-08-28 US disclosed
EP-0001603-A2 Process for preparing isocyanates BAYER AG (DE) 1979-05-02 EP disclosed