SCHEMBL841779

SCHEMBL841779

Nc1nc2ccccc2c(N)c1N

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 7/20 0.70
ALDH1A1 P00352 6/20 0.70
ACHE P22303 6/20 0.70
KDM4E B2RXH2 4/20 0.70
HPGD P15428 4/20 0.70
GLA P06280 2/20 0.70
CASP1 P29466 2/20 0.70
CASP7 P55210 2/20 0.70
SMN1; SMN2 Q16637 2/20 0.70
CHRM2 P08172 2/20 0.70
ADRA2A P08913 2/20 0.70
ADORA3 P0DMS8 2/20 0.70
CHRM1 P11229 2/20 0.70
SLC6A2 P23975 2/20 0.70
OPRM1 P35372 2/20 0.70
KCNH2 Q12809 2/20 0.70
NQO2 P16083 1/20 0.70
MAOA P21397 1/20 0.70
DRD1 P21728 1/20 0.70
ADRA1A P35348 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29809559 1.00 HSD17B10 (0.70) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL29354393 0.82 HSD17B10 (1.00) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL14999 0.82 HSD17B10 (1.00) HSD17B10ALDH1A1ACHEKDM4EHPGD
SCHEMBL6833669 0.80 ALDH1A1 (0.61) HSD17B10ALDH1A1ACHEKDM4EHPGD
SCHEMBL27300595 0.80 ACHE (0.61) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL4907467 0.80 HSD17B10 (0.95) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL635597 0.80 RAB9A (1.00) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL14482032 0.80 HSD17B10 (0.95) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL30355377 0.80 HSD17B10 (0.95) HSD17B10ALDH1A1ACHEKDM4EHPGD
Aminacrine SCHEMBL18989123 0.80 HSD17B10 (0.95) HSD17B10ALDH1A1ACHEKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2182914-B1 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF L'ORÉAL (FR) 2017-11-08 EP claimed
US-8043385-B2 Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof L'OREAL S.A. (FR) 2011-10-25 US claimed
US-8002847-B2 Composition for oxidation dyeing keratin fibres comprising a cationic cellulose ether, a weakly oxyethylenated sorbitan fatty acid ester and oxidation dyes L 'OREAL S.A. (FR) 2011-08-23 US claimed
US-20100263138-A1 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF L'OREAL S.A. (FR) 2010-10-21 US claimed
EP-2175830-A2 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES L'Oreal (FR) 2010-04-21 EP claimed
EP-1413286-B1 Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent OREAL (FR) 2009-04-22 EP claimed
WO-2009016061-A2 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES L'OREAL (FR) 2009-02-05 WO claimed
WO-2007071688-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
CN-115210253-A Nestin-based scaffold proteins and therapeutic nanoconjugates 巴塞罗那自治大学 2022-10-18 CN disclosed
CN-210037730-U Mass spectrum analysis device 中国科学院化学研究所 2020-02-07 CN disclosed
EP-2175830-B1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES ORÉAL L (FR) 2015-09-30 EP disclosed
US-8143270-B2 2-amino 1H-in-imidazo ring systems and methods 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-03-27 US disclosed
US-8043385-B2 Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof L'OREAL S.A. (FR) 2011-10-25 US disclosed
US-8002847-B2 Composition for oxidation dyeing keratin fibres comprising a cationic cellulose ether, a weakly oxyethylenated sorbitan fatty acid ester and oxidation dyes L 'OREAL S.A. (FR) 2011-08-23 US disclosed
EP-1784180-A2 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-05-16 EP disclosed
WO-2006029115-A2 2-AMINO 1H IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-03-16 WO disclosed
EP-1413286-A1 Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent L'OREAL (FR) 2004-04-28 EP disclosed
US-5770734-A N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-23 US disclosed
US-5149815-A Anticholirergic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-09-22 US disclosed
US-5093333-A N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system AMERICAN HOME PRODUCTS CORPORATION (US) 1992-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100263138-A1 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF KRT18, TUBB3, VIM HSD17B10 2097/4885ALDH1A1 1691/4885ACHE 1232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.