Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423779 | 0.96 | MAPT (0.40) | MAPTALDH1A1HPGDHTTKAT6A | |
| SCHEMBL8421856 | 0.90 | KDM1A (0.41) | MAPTALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL8420103 | 0.88 | PTGS2 (0.45) | MAPTKAT6ALMNAKDM1APGR | |
| SCHEMBL8641119 | 0.88 | AURKA (0.46) | MAPTHTTKAT6AGAAKDM4E | |
| SCHEMBL8422282 | 0.87 | KDM1A (0.43) | MAPTALDH1A1HPGDHTTKAT6A | |
| SCHEMBL8421776 | 0.87 | KDM1A (0.47) | MAPTHTTKAT6AGAAKDM4E | |
| SCHEMBL8424142 | 0.85 | KAT6A (0.47) | ALDH1A1HPGDKAT6ALMNAGAA | |
| SCHEMBL8423597 | 0.85 | KAT6A (0.42) | MAPTALDH1A1HPGDHTTKAT6A | |
| SCHEMBL8421734 | 0.85 | KDM1A (0.43) | MAPTHTTKAT6ALMNAGAA | |
| SCHEMBL8420734 | 0.85 | MALT1 (0.43) | MAPTKAT6AGAAKDM1APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |