Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL6365192 | 0.89 | CHRM2 (0.40) | HTTLMNAKMT2ACHRM2CHRM1 | |
| Bicarbonate SCHEMBL5227 | 0.88 | ALDH1A1 (0.41) | HTTLMNAKMT2ACHRM2CHRM1 | |
| SCHEMBL2417 | 0.86 | ALDH1A1 (0.45) | HTTLMNAKMT2ACHRM2CHRM1 | |
| SCHEMBL9790 | 0.86 | ALDH1A1 (0.45) | HTTLMNAKMT2ACHRM2CHRM1 | |
| SCHEMBL2229127 | 0.86 | ALDH1A1 (0.45) | HTTLMNAKMT2ACHRM2CHRM1 | |
| Acetic Acid SCHEMBL1802264 | 0.84 | TERT (0.41) | HTTCHRM2CHRM1ALDH1A1KDM4E | |
| Isopropyl Alcohol SCHEMBL7567318 | 0.84 | KMT2A (0.41) | HTTLMNAKMT2ACHRM2CHRM1 | |
| SCHEMBL21752879 | 0.84 | ALDH1A1 (0.43) | HTTLMNAKMT2ACHRM2CHRM1 | |
| SCHEMBL21752846 | 0.84 | ALDH1A1 (0.43) | HTTLMNAKMT2ACHRM2CHRM1 | |
| Sulfuric Acid SCHEMBL6545396 | 0.84 | ALDH1A1 (0.43) | HTTLMNAKMT2ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941065-A1 | IONOPHORE-MEDIATED LIPOSOME LOADING OF WEAKLY BASIC DRUG | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1999-09-15 | — | — | EP | disclosed |
| US-5837282-A | DRUG DELIVERY; ENCAPSULATION OF A WEAKLY BASIC DRUG | UNIVERSITY OF BRITISH COLUMBIA (CA) | 1998-11-17 | — | — | US | disclosed |
| WO-1998018450-A1 | IONOPHORE-MEDIATED LIPOSOME LOADING OF WEAKLY BASIC DRUG | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1998-05-07 | — | — | WO | disclosed |