SCHEMBL8420591

SCHEMBL8420591

Nc1ccc(CNCCCCCC(=O)O)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.68
S1PR1 P21453 2/20 0.58
S1PR3 Q99500 2/20 0.58
S1PR2 O95136 1/20 0.58
HDAC3 O15379 6/20 0.55
HDAC1 Q13547 6/20 0.55
HDAC2 Q92769 6/20 0.55
HDAC8 Q9BY41 6/20 0.55
NCOR2 Q9Y618 2/20 0.55
HDAC4 P56524 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52
HDAC5 Q9UQL6 2/20 0.52
MAOA P21397 1/20 0.50
CHRM2 P08172 4/20 0.49
MAPK1 P28482 1/20 0.46
FOLH1 Q04609 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20184745 0.86 S1PR1 (0.49) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL16374750 0.85 ALDH1A1 (0.69) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL28329735 0.85 HDAC3 (0.73) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL7204842 0.85 HDAC3 (0.73) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL11775902 0.85 HDAC3 (0.73) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL17026711 0.84 CHRM2 (0.69) ALDH1A1S1PR1S1PR3S1PR2HDAC3
Hydrochloric Acid SCHEMBL3229769 0.83 HDAC3 (0.71) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL15694807 0.83 ALDH1A1 (0.67) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL8905341 0.83 HDAC3 (0.73) ALDH1A1S1PR1S1PR3S1PR2HDAC3
SCHEMBL24376041 0.80 CHRM2 (0.71) ALDH1A1S1PR1S1PR3S1PR2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0600936-B1 DIFFERENTIAL BINDING AFFINITIES AND DISSOCIATION ASSAYS BASED THEREON SEREX INC (US) 1999-10-06 EP disclosed
EP-0600936-A4 DIFFERENTIAL BINDING AFFINITIES AND DISSOCIATION ASSAYS BASED THEREON. SEREX INC (US) 1996-08-28 EP disclosed
US-5527686-A DETECTING COTININE BY CONTACT WITH RECEPTOR-LIGAND COMPLEX WHICH DISSOCIATES, RECEPTOR BINDING WITH COTININE; RELEASE ASSAY SEREX, INC. (US) 1996-06-18 US disclosed
EP-0600936-A1 DIFFERENTIAL BINDING AFFINITIES AND DISSOCIATION ASSAYS BASED THEREON SEREX, INC. (US) 1994-06-15 EP disclosed
WO-1993003367-A1 DIFFERENTIAL BINDING AFFINITIES AND DISSOCIATION ASSAYS BASED THEREON SEREX, INC. (US) 1993-02-18 WO disclosed