Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 2/20 | 0.33 |
| ▸ | PGK2 | P07205 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 3/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605208 | 0.84 | ALDH1A1 (0.34) | HPGDCETPMMP1FOLH1GAA | |
| SCHEMBL5059999 | 0.80 | FOLH1 (0.38) | CETPMMP1FOLH1 | |
| SCHEMBL7610491 | 0.79 | CETP (0.35) | HPGDTSHRCETPMMP1FOLH1 | |
| SCHEMBL7605932 | 0.78 | PTPN1 (0.52) | PGK1PGK2CETPPTPN1 | |
| SCHEMBL7609232 | 0.77 | CETP (0.36) | HPGDCETPMMP1FOLH1 | |
| SCHEMBL8425910 | 0.77 | KCNA5 (0.46) | FDPS | |
| SCHEMBL7772647 | 0.74 | HPGD (0.46) | HPGDTSHRCETPFDPSMMP1 | |
| SCHEMBL7610589 | 0.73 | ALDH1A1 (0.44) | PGK1PGK2HPGDTSHRPTPN1 | |
| SCHEMBL7607525 | 0.73 | MMP1 (0.37) | HPGDMMP1MMP3MMP13 | |
| SCHEMBL7606830 | 0.72 | RAB9A (0.35) | HPGDMMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | disclosed |