SCHEMBL8425765

SCHEMBL8425765

Cc1cn(-c2cccc(OC(F)F)c2)c(=NC(=O)C(F)Cl)s1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.40
LMNA P02545 3/20 0.39
MAPT P10636 3/20 0.39
ALDH1A1 P00352 1/20 0.39
NPSR1 Q6W5P4 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
GAA P10253 1/20 0.34
RXRA P19793 5/20 0.34
GRIN1 Q05586 5/20 0.34
GRIN2B Q13224 5/20 0.34
FBP1 P09467 1/20 0.34
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
GRM4 Q14833 2/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8425430 0.91 NPC1 (0.42) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL8424571 0.90 CNR1 (0.38) RAB9ANPC1LMNARXRAGRIN1
SCHEMBL8428131 0.88 NPC1 (0.40) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL8428107 0.87 PKM (0.37) RAB9ANPC1MAPTALDH1A1GAA
SCHEMBL8428211 0.87 NPC1 (0.39) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL8428409 0.83 CNR2 (0.43) ALDH1A1NPSR1SMN1; SMN2
SCHEMBL8427939 0.81 CNR1 (0.38) RAB9ANPC1MAPTRXRAGRIN1
SCHEMBL8423732 0.80 USP2 (0.34) NPSR1
SCHEMBL8424264 0.79 GABRA2 (0.35) RAB9ANPC1MAPTALDH1A1GAA
SCHEMBL8424639 0.76 GABRA2 (0.34) RAB9ANPC1MAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed