SCHEMBL8424639

SCHEMBL8424639

Cc1cn(-c2cccc(Cl)c2)c(=NC(=O)C(F)C(F)(F)F)s1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA2 P47869 1/20 0.34
GABRB2 P47870 1/20 0.34
CNR2 P34972 2/20 0.33
PKM P14618 1/20 0.33
NOTUM Q6P988 1/20 0.33
SCN2B O60939 1/20 0.33
SCN1A P35498 1/20 0.33
SCN1B Q07699 1/20 0.33
SCN5A Q14524 1/20 0.33
SCN9A Q15858 1/20 0.33
TP53 P04637 1/20 0.32
HSD17B10 Q99714 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
NPY5R Q15761 1/20 0.32
MLYCD O95822 1/20 0.32
ALDH1A1 P00352 2/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8427940 0.91 CNR2 (0.35) GABRA2GABRB2CNR2PKMNOTUM
SCHEMBL8424264 0.90 GABRA2 (0.35) GABRA2GABRB2CNR2PKMNOTUM
SCHEMBL8428107 0.88 PKM (0.37) GABRA2GABRB2CNR2PKMNOTUM
SCHEMBL8428041 0.88 USP2 (0.33)
SCHEMBL8425725 0.88 CNR2 (0.43) CNR2NOTUMSCN2BSCN1ASCN1B
SCHEMBL8428131 0.87 NPC1 (0.40) CNR2MEN1KMT2AALDH1A1GAA
SCHEMBL8427939 0.86 CNR1 (0.38) CNR2NOTUMNPY5RMAPTNPC1
SCHEMBL8425518 0.82 AR (0.36) NOTUMTP53MAPT
SCHEMBL8428409 0.80 CNR2 (0.43) CNR2NOTUMSCN2BSCN1ASCN1B
SCHEMBL8424239 0.80 CNR2 (0.44) CNR2NOTUMSCN2BSCN1ASCN1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed