Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.64 |
| ▸ | LMNA | P02545 | 8/20 | 0.64 |
| ▸ | PGR | P06401 | 7/20 | 0.64 |
| ▸ | AR | P10275 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinonide SCHEMBL616754 | 0.87 | NR3C1 (0.74) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinolone Acetonide SCHEMBL8450831 | 0.82 | NR3C1 (0.77) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL5664031 | 0.82 | NR3C1 (0.62) | HIF1ALMNAPGRNR3C1AR | |
| Difluprednate SCHEMBL4959751 | 0.81 | LMNA (0.66) | HIF1ALMNAPGRNR3C1AR | |
| Amcinonide SCHEMBL22684943 | 0.80 | NR3C1 (0.64) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL9338347 | 0.80 | HIF1A (1.00) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL13072779 | 0.80 | HIF1A (1.00) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL2800723 | 0.80 | HIF1A (1.00) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL13568069 | 0.80 | HIF1A (1.00) | HIF1ALMNAPGRNR3C1AR | |
| Fluocinonide SCHEMBL4262 | 0.80 | HIF1A (1.00) | HIF1ALMNAPGRNR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946146-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | Boehringer Ingelheim Pharma KG (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027959-A2 | NEW AQUEOUS MEDICAMENT PREPARATIONS FOR THE PRODUCTION OF PROPELLENT GAS-FREE AEROSOLS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-07-02 | — | — | WO | disclosed |
| EP-0835098-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997001329-A1 | NEW, STABLE MEDICINAL COMPOSITIONS FOR GENERATING PROPELLANT-FREE AEROSOLS | BOEHRINGER INGELHEIM KG (DE) | 1997-01-16 | — | — | WO | disclosed |