Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 17/20 | 0.40 |
| ▸ | TACR2 | P21452 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425245 | 0.82 | ADRA1D (0.39) | TACR3TACR2TACR1ADRA2AADRA2B | |
| SCHEMBL6160860 | 0.74 | TACR2 (0.62) | TACR3TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8425489 | 0.70 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8425178 | 0.69 | ALDH1A1 (0.36) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8425278 | 0.69 | P2RX7 (0.43) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL6161088 | 0.63 | TACR2 (0.61) | TACR3TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL7988071 | 0.63 | TACR2 (0.61) | TACR3TACR2TACR1 | |
| SCHEMBL2478765 | 0.62 | TACR3 (0.53) | TACR3TACR2TACR1 | |
| SCHEMBL2480008 | 0.62 | TACR3 (0.50) | TACR3TACR2TACR1 | |
| Hydrochloric Acid SCHEMBL8364985 | 0.62 | TACR3 (0.46) | TACR3TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889024-A | Substituted heterocycles | ZENECA LIMITED (GB) | 1999-03-30 | — | — | US | disclosed |