SCHEMBL8428274

SCHEMBL8428274

C=C(C)C(=O)c1cccc(-c2cccc3nn(O)nc23)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 3/20 0.35
HRH4 Q9H3N8 1/20 0.35
FYN P06241 5/20 0.35
MAP4K4 O95819 2/20 0.35
CLK4 Q9HAZ1 2/20 0.35
AURKA O14965 1/20 0.35
DAPK3 O43293 1/20 0.35
JAK2 O60674 1/20 0.35
ABL1 P00519 1/20 0.35
NTRK1 P04629 1/20 0.35
CSF1R P07333 1/20 0.35
RET P07949 1/20 0.35
FGFR1 P11362 1/20 0.35
PRKACA P17612 1/20 0.35
KDR P35968 1/20 0.35
MAP2K2 P36507 1/20 0.35
MAPK8 P45983 1/20 0.35
CDK8 P49336 1/20 0.35
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1643503 0.76 ENPP1 (0.41) FYNMAP4K4CLK4ABL1NTRK1
SCHEMBL28608544 0.72 KIF11 (0.43)
SCHEMBL8645604 0.69 COMT (0.39) MEN1KMT2A
SCHEMBL2730925 0.69 PTGS2 (0.39) MEN1KMT2A
SCHEMBL28511468 0.69 CNR1 (0.45)
SCHEMBL27589462 0.67 KAT6A (0.48) MAP4K4CLK4AURKADAPK3JAK2
SCHEMBL8334072 0.64 CNR1 (0.37)
SCHEMBL28461145 0.64 NPC1 (0.35) DHFR
SCHEMBL9741815 0.63 KMT2A (0.38) KMT2A
SCHEMBL5854006 0.63 CA12 (0.55) DYRK1BMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727442-B1 Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK CO (US) 1999-10-20 EP disclosed
US-5747585-A Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK COMPANY (US) 1998-05-05 US disclosed
EP-0727442-A2 Process for synthesizing latex polymers from solid monomer particles EASTMAN KODAK COMPANY (US) 1996-08-21 EP disclosed