SCHEMBL8428345

SCHEMBL8428345

CCOCCn1c(-c2ccc(Cl)cc2)c(C#N)c(Br)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOBEC3G Q9HC16 1/20 0.34
GRIA2 P42262 1/20 0.34
GRIA4 P48058 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
EIF4EBP1 Q13541 1/20 0.33
MYC P01106 1/20 0.32
KDM4E B2RXH2 4/20 0.32
ALDH1A1 P00352 3/20 0.32
HPGD P15428 3/20 0.32
KMT2A Q03164 3/20 0.32
HTT P42858 2/20 0.32
MEN1 O00255 2/20 0.32
LMNA P02545 2/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
CRHBP P24387 1/20 0.32
CRHR2 Q13324 1/20 0.32
TGFBR1 P36897 1/20 0.32
PIK3CD O00329 1/20 0.31
PIK3R2 O00459 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorfenapyr SCHEMBL40337 0.89 RXFP1 (0.35) GRIA2GRIA4RXFP1KDM4EALDH1A1
Chlorfenapyr SCHEMBL28530561 0.88 RXFP1 (0.35) GRIA2GRIA4RXFP1KDM4EALDH1A1
Chlorfenapyr SCHEMBL27488880 0.88 RXFP1 (0.35) GRIA2GRIA4RXFP1KDM4EALDH1A1
Chlorfenapyr SCHEMBL28508419 0.87 RXFP1 (0.36) GRIA2GRIA4RXFP1KDM4EALDH1A1
SCHEMBL9301702 0.84 KDM4E (0.33) GRIA2GRIA4RXFP1KDM4EALDH1A1
Chlorfenapyr SCHEMBL28402415 0.83 RXFP1 (0.32) GRIA2GRIA4RXFP1KDM4EALDH1A1
SCHEMBL27916628 0.82 KDM4E (0.33) KDM4EALDH1A1HPGDKMT2AHTT
SCHEMBL5819212 0.82 KDM4E (0.34) GRIA2GRIA4RXFP1KDM4EALDH1A1
Chlorfenapyr SCHEMBL16446552 0.82 MEN1 (0.35) GRIA2GRIA4RXFP1KDM4EALDH1A1
SCHEMBL7499361 0.81 KDM4E (0.37) GRIA2GRIA4RXFP1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778268-B1 Trifluoromethanesulfinanilide compound and use thereof SUMITOMO CHEMICAL CO (JP) 1999-11-03 EP disclosed
US-5698591-A Trifluoromethanesulfinanilide, process for preparing trifluoromethanesulfonanilide from the same, and a controlling agent formulated from trifluoromethanesulfinanilide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
EP-0778268-A1 Trifluoromethanesulfinanilide compound and use thereof SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-06-11 EP disclosed