SCHEMBL8428522

SCHEMBL8428522

Cn1cncc2nccc1-2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 1/20 0.43
IDO1 P14902 3/20 0.42
LDLR P01130 1/20 0.40
PCSK9 Q8NBP7 1/20 0.40
CYP17A1 P05093 2/20 0.38
CYP1A2 P05177 1/20 0.38
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
CYP2A6 P11509 2/20 0.34
HTR6 P50406 5/20 0.34
HTR2A P28223 2/20 0.34
KCNH2 Q12809 1/20 0.34
HTR1A P08908 4/20 0.33
HTR7 P34969 4/20 0.33
DRD2 P14416 1/20 0.33
CYP2E1 P05181 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2B6 P20813 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16462472 0.71 RECQL (0.41) HPGDSIDO1LDLRPCSK9CYP17A1
SCHEMBL17601377 0.71 IDO1 (0.44) HPGDSIDO1LDLRPCSK9CYP17A1
SCHEMBL30363640 0.71 IDO1 (0.44) HPGDSIDO1LDLRPCSK9CYP17A1
SCHEMBL30151475 0.69 FGFR1 (0.44) LDLRPCSK9KCNH2CYP2C9GSK3B
SCHEMBL21241079 0.68 IDO1 (0.53) HPGDSIDO1LDLRPCSK9WNT1
SCHEMBL15002051 0.68 ALDH1A1 (0.44) PCSK9CYP1A2CCR1CCR5CCR8
SCHEMBL30834345 0.68 LDLR (0.41) HPGDSIDO1LDLRPCSK9CYP17A1
SCHEMBL9592630 0.68 CYP11B1 (0.44) CYP1A2CYP2C9CYP2C19
SCHEMBL16655828 0.68 SORD (0.41) HPGDSIDO1LDLRPCSK9CYP17A1
SCHEMBL30834347 0.67 PDPK1 (0.43) HPGDSIDO1LDLRPCSK9CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5929081-A ADMINISTERING COMPOUND THAT INHIBITS SIGNAL TRANSDUCTION THROUGH CELLULAR ACCUMULATION OF NON-ARACHIDONYL PHOSPHATIDIC ACID CELL THERAPEUTICS INC. (US) 1999-07-27 US claimed