Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGAV | P06756 | 4/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPRA | P18433 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430895 | 0.76 | DHODH (0.41) | DHODHPAX8ITGB3ITGAVF10 | |
| SCHEMBL8429036 | 0.72 | DHODH (0.51) | DHODHPAX8ITGB3ITGAVF10 | |
| SCHEMBL8432249 | 0.72 | CYP17A1 (0.35) | DHODHPAX8ITGB3ITGAVHDAC6 | |
| SCHEMBL8432423 | 0.67 | DHODH (0.40) | DHODHPAX8ITGB3ITGAVALDH1A1 | |
| SCHEMBL8542542 | 0.67 | ITGB3 (0.39) | DHODHPAX8ITGB3ITGAVALDH1A1 | |
| SCHEMBL27113200 | 0.65 | CYP3A4 (0.54) | MAP4K4ALDH1A1MAPK1HPGDSMN1; SMN2 | |
| SCHEMBL8409079 | 0.65 | HDAC6 (0.54) | HDAC6 | |
| SCHEMBL27115412 | 0.64 | TERT (0.49) | F2RMAP4K4HDAC6CYP3A4CYP2D6 | |
| SCHEMBL8432464 | 0.64 | DHODH (0.43) | DHODHITGB3ITGAVF10 | |
| SCHEMBL8409081 | 0.62 | LMNA (0.46) | ITGB3HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |