Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 5/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432423 | 0.92 | DHODH (0.40) | DHODHSYKCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8430846 | 0.86 | F10 (0.41) | CYP4F2CYP4A11ALDH1A1GAAF9 | |
| SCHEMBL8429036 | 0.79 | DHODH (0.51) | DHODHGAAF10PAX8MGLL | |
| SCHEMBL8428869 | 0.76 | DHODH (0.34) | DHODHALDH1A1F10PAX8ITGB3 | |
| SCHEMBL8532684 | 0.73 | ENPP2 (0.35) | DHODHSYKCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL8432817 | 0.72 | CYP17A1 (0.33) | — | |
| SCHEMBL8432249 | 0.71 | CYP17A1 (0.35) | DHODHPAX8ITGB3ITGAV | |
| SCHEMBL8432464 | 0.71 | DHODH (0.43) | DHODHF10MGLLITGB3ITGAV | |
| SCHEMBL8430854 | 0.70 | DHODH (0.43) | DHODHALDH1A1F10MGLLITGB3 | |
| SCHEMBL8432812 | 0.70 | ITGB3 (0.39) | PAX8ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |