Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430895 | 0.79 | DHODH (0.41) | DHODHITGB3ITGAVMGLLF10 | |
| SCHEMBL8431259 | 0.73 | RXFP1 (0.43) | KDM4EMAPTPLAU | |
| SCHEMBL8432464 | 0.73 | DHODH (0.43) | DHODHITGB3ITGAVMGLLF10 | |
| SCHEMBL8428869 | 0.72 | DHODH (0.34) | DHODHITGB3ITGAVHPGDNPSR1 | |
| SCHEMBL8432423 | 0.71 | DHODH (0.40) | DHODHITGB3ITGAVMGLLGAA | |
| SCHEMBL8430854 | 0.70 | DHODH (0.43) | DHODHITGB3ITGAVMGLLHPGD | |
| SCHEMBL8432249 | 0.69 | CYP17A1 (0.35) | DHODHITGB3ITGAVKDM4ECYP3A4 | |
| SCHEMBL8542542 | 0.69 | ITGB3 (0.39) | DHODHITGB3ITGAVKDM4EHPGD | |
| SCHEMBL27113200 | 0.68 | CYP3A4 (0.54) | KDM4EHPGDHSD17B10CYP3A4CYP2D6 | |
| SCHEMBL27115412 | 0.67 | TERT (0.49) | MGLLCYP3A4CYP2D6CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |