Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 4/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429206 | 0.73 | ENPP2 (0.38) | ENPP2MGLLCFDHDAC1 | |
| SCHEMBL8430895 | 0.70 | DHODH (0.41) | DHODHF10ALDH1A1ITGB3ITGAV | |
| SCHEMBL8429036 | 0.70 | DHODH (0.51) | DHODHF10MAPTHPGDITGB3 | |
| SCHEMBL27113200 | 0.66 | CYP3A4 (0.54) | LMNAMAPTMEN1ALDH1A1HPGD | |
| SCHEMBL8687140 | 0.65 | KMT2A (0.65) | LMNAMAPTMEN1ALDH1A1HPGD | |
| SCHEMBL25277661 | 0.65 | MGLL (0.61) | MGLLCFDHDAC1 | |
| SCHEMBL8432464 | 0.64 | DHODH (0.43) | DHODHF10ITGB3ITGAVMGLL | |
| SCHEMBL27115412 | 0.62 | TERT (0.49) | MGLLCFDHDAC1 | |
| Nitrous Acid SCHEMBL5997813 | 0.62 | F10 (0.44) | F10LMNAMAPTMEN1ALDH1A1 | |
| SCHEMBL9721920 | 0.62 | LMNA (0.62) | DHODHLMNAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |