Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 11/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | C1R | P00736 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 6/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716801 | 0.82 | NPC1 (0.47) | NPC1ALDH1A1GAAPPARGPPARA | |
| SCHEMBL8429714 | 0.74 | ALDH1A1 (0.36) | NPC1ALDH1A1GAAMAPTMEN1 | |
| SCHEMBL6205162 | 0.73 | CA1 (0.41) | NPC1ALDH1A1GAAMAPTMEN1 | |
| SCHEMBL8429668 | 0.71 | PPARG (0.53) | ALDH1A1PPARGPPARA | |
| SCHEMBL8716289 | 0.70 | PPARG (0.48) | NPC1ALDH1A1PPARGPPARAPPARD | |
| SCHEMBL8716282 | 0.70 | PPARG (0.47) | NPC1ALDH1A1PPARGPPARA | |
| SCHEMBL10431312 | 0.67 | SMN1; SMN2 (0.45) | NPC1ALDH1A1GAAMAPTHDAC6 | |
| SCHEMBL6591666 | 0.66 | MAPT (0.46) | NPC1ALDH1A1GAAPPARGMAPT | |
| SCHEMBL7830197 | 0.66 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL4744468 | 0.66 | PPARG (0.63) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869495-A | TREATMENT AND/OR PROPHYLAXIS OF HYPERGLYCAEMIA | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-02-09 | — | — | US | disclosed |