Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PROC | P04070 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430895 | 0.86 | DHODH (0.41) | F10CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL8432423 | 0.84 | DHODH (0.40) | CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL8432620 | 0.80 | F10 (0.38) | F10F2PRSS1PLGPROC | |
| SCHEMBL8534458 | 0.75 | F10 (0.43) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8429101 | 0.68 | PTGER4 (0.47) | F10F2PRSS1PLGPROC | |
| SCHEMBL7379154 | 0.68 | PLAU (0.55) | F10F2PRSS1CYP4F2CYP4A11 | |
| SCHEMBL7376449 | 0.68 | F10 (0.52) | F10F2PRSS1CYP4F2CYP4A11 | |
| SCHEMBL7380693 | 0.67 | F10 (0.51) | F10F2PRSS1 | |
| SCHEMBL7372797 | 0.67 | ITGB3 (0.60) | F10F2PRSS1PLG | |
| SCHEMBL8567923 | 0.66 | CYP4F2 (0.58) | CYP4F2CYP4A11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |