Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433730 | 0.82 | SLC6A4 (0.50) | KMT2AL3MBTL1GAAPOLBMEN1 | |
| SCHEMBL22369511 | 0.80 | GAA (0.55) | KMT2AL3MBTL1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6638095 | 0.71 | POLB (0.59) | KMT2AL3MBTL1CYP2D6GAAPOLB | |
| SCHEMBL27545152 | 0.71 | ALDH1A1 (0.59) | KMT2AL3MBTL1CYP2C19POLBPTPRC | |
| SCHEMBL8631418 | 0.71 | POLB (0.53) | KMT2AL3MBTL1CYP2C9CYP2C19POLB | |
| SCHEMBL27277381 | 0.70 | KMT2A (0.50) | KMT2AL3MBTL1POLBPTPRCNPY2R | |
| SCHEMBL7289139 | 0.70 | EPHX2 (0.60) | KMT2AL3MBTL1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10685152 | 0.69 | KMT2A (0.49) | KMT2AL3MBTL1POLBPTPRCNPY2R | |
| SCHEMBL8960943 | 0.69 | MTNR1A (0.52) | KMT2AL3MBTL1CYP2C19MEN1TSHR | |
| SCHEMBL9509549 | 0.69 | KMT2A (0.43) | KMT2AL3MBTL1CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5945454-A | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives | PHARMACIA & UPJOHN, S.P.A. (IT) | 1999-08-31 | — | — | US | disclosed |