Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432187 | 0.76 | PDE1A (0.36) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL8419860 | 0.76 | TNKS2 (0.38) | HTR2AHTR2CHTR2BCYP19A1KDM4E | |
| SCHEMBL9757485 | 0.75 | IMPDH2 (0.35) | — | |
| SCHEMBL3339987 | 0.71 | HMGCR (0.44) | HTR2AHTR2CCYP19A1KDM4ENPC1 | |
| SCHEMBL11871207 | 0.70 | IMPDH2 (0.33) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL4590543 | 0.70 | ATP4A (0.43) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL8036573 | 0.70 | MAPT (0.48) | HTR2AHTR2CHTR2BCYP19A1KDM4E | |
| SCHEMBL10621551 | 0.70 | ACHE (0.43) | KDM4EPOLBNPC1MAPTCYP3A4 | |
| SCHEMBL7865943 | 0.69 | L3MBTL1 (0.44) | KDM4EPOLBNPC1MAPTCYP3A4 | |
| SCHEMBL30665721 | 0.69 | NPC1 (0.45) | CYP19A1KDM4EPOLBNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0847749-B1 | Use of diiminoisoindoline or 3-aminoisoindolone derivatives for the dyeing of keratinic fibers and compositions containing them | OREAL (FR) | 1999-12-01 | — | — | EP | disclosed |
| EP-0847749-A1 | Use of diiminoisoindoline or 3-aminoisoindolone derivatives for the dyeing of keratinic fibers and compositions containing them | L'OREAL (FR) | 1998-06-17 | — | — | EP | disclosed |
| US-5015772-A | Hair dyes | L'OREAL (FR) | 1991-05-14 | — | — | US | disclosed |
| US-4960432-A | Meta-phenylenediamines, process for preparation thereof, intermediate compounds and use of these meta-phenylenediamines as couplers for the oxidation dyeing of keratinous fibres and especially human hair | L'OREAL (FR) | 1990-10-02 | — | — | US | disclosed |