Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6475701 | 0.80 | ATP4A (0.44) | ATP4AATP4BHTR2CHTR1AHTR1D | |
| SCHEMBL8419860 | 0.73 | TNKS2 (0.38) | HTR2CTAAR1GAAALDH1A1MAPT | |
| SCHEMBL30735529 | 0.71 | GAA (0.47) | ATP4AATP4BHTR2CHTR1AHTR1D | |
| SCHEMBL2826069 | 0.70 | MAPT (0.55) | ATP4AATP4BHTR2CHTR1AHTR1D | |
| SCHEMBL8433353 | 0.70 | PDE1A (0.40) | HTR2CGAANPC1ALDH1A1MAPT | |
| SCHEMBL3416775 | 0.69 | KMT2A (0.40) | TAAR1ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL2827212 | 0.69 | GAA (0.42) | ATP4AATP4BHTR2CHTR1AHTR1D | |
| SCHEMBL24945820 | 0.68 | TAAR1 (0.55) | HTR2CTAAR1ALDH1A1LMNAHTT | |
| SCHEMBL31187890 | 0.67 | ACHE (0.48) | ALDH1A1KDM4ETNKS2SMN1; SMN2 | |
| SCHEMBL26091619 | 0.67 | NPC1 (0.42) | HTR2CHTR1AHTR1DHTR7HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899307-A1 | 8-ALK0XY-4-METHYL-3, 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. Hoffmann-Roche AG (CH) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000393-A1 | 8-ALK0XY-4-METHYL-3 , 4-DIHYDR0-QUINAZ0LIN-2-YL AMINES AND THEIR USE AS 5-HT5A RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-04 | — | — | WO | disclosed |