SCHEMBL8433475

SCHEMBL8433475

O=[N+]([O-])c1cc(-c2nc3ccccc3s2)cc([N+](=O)[O-])c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 5/20 0.76
MMP9 P14780 2/20 0.76
MMP8 P22894 2/20 0.76
MMP13 P45452 2/20 0.76
MMP2 P08253 1/20 0.76
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
MAPT P10636 3/20 0.53
MAPK1 P28482 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ILK Q13418 1/20 0.53
KDM4E B2RXH2 4/20 0.52
ALDH1A1 P00352 4/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
HPGD P15428 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
RAB9A P51151 5/20 0.51
NPC1 O15118 4/20 0.51
CYP3A4 P08684 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8396940 0.88 APP (0.72) APPMMP9MMP8MMP13MMP2
SCHEMBL1992041 0.86 APP (1.00) APPMMP9MMP8MMP13MMP2
SCHEMBL20508279 0.84 MMP13 (0.59) APPMMP9MMP8MMP13MMP2
SCHEMBL4224543 0.83 APP (0.86) APPMMP9MMP8MMP13MMP2
SCHEMBL13053014 0.80 RAB9A (0.69) APPMMP9MMP8MEN1KMT2A
SCHEMBL1666128 0.79 APP (0.68) APPMMP9MMP8MMP13MMP2
SCHEMBL8532307 0.79 APP (0.67) APPMMP9MMP8MMP13MMP2
SCHEMBL27909857 0.79 APP (0.84) APPMMP9MMP8MMP13MMP2
SCHEMBL18430440 0.78 MMP13 (0.62) APPMMP9MMP8MMP13MMP2
SCHEMBL14939305 0.78 RAB9A (0.67) APPMMP9MMP8MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0590620-B1 Silver halide emulsions stabilized with improved antifoggants STERLING DIAGNOSTIC IMAGING (US) 1999-12-08 EP disclosed
US-5409809-A Silver halide emulsions stabilized with improved antifoggants E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-04-25 US disclosed
EP-0590620-A1 Silver halide emulsions stabilized with improved antifoggants E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-04-06 EP disclosed