Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433630 | 1.00 | TRPV1 (0.36) | TRPV1PTGS1ERBB2NQO2PDE2A | |
| Hydrochloric Acid SCHEMBL8438263 | 0.99 | TRPV1 (0.36) | TRPV1PTGS1ERBB2NQO2PDE2A | |
| Hydrochloric Acid SCHEMBL8438272 | 0.99 | TRPV1 (0.36) | TRPV1PTGS1ERBB2NQO2PDE2A | |
| SCHEMBL8437451 | 0.84 | RAB9A (0.47) | CYP1A2CASP3SENP8SENP7SENP6 | |
| SCHEMBL8437447 | 0.84 | RAB9A (0.47) | CYP1A2CASP3SENP8SENP7SENP6 | |
| Hydrochloric Acid SCHEMBL8433464 | 0.83 | RAB9A (0.46) | CYP1A2CASP3SENP8SENP7SENP6 | |
| SCHEMBL8433718 | 0.82 | CASP3 (0.41) | PTGS1NQO2CYP1A2AHRCASP3 | |
| SCHEMBL8433710 | 0.82 | CASP3 (0.41) | PTGS1NQO2CYP1A2AHRCASP3 | |
| Hydrochloric Acid SCHEMBL8434955 | 0.81 | CASP3 (0.40) | PTGS1NQO2CYP1A2AHRCASP3 | |
| SCHEMBL8434220 | 0.73 | NOS3 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |