Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.61 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.61 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.61 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.61 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437928 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL6588716 | 0.93 | CHRNA3 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL7472876 | 0.93 | CHRNA3 (0.59) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL8436877 | 0.90 | CHEK2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL7372804 | 0.88 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL7371666 | 0.88 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL18291353 | 0.87 | ALOX5AP (0.57) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL7418829 | 0.87 | ALOX5AP (0.53) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL18291345 | 0.87 | ALOX5AP (0.57) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL2200111 | 0.86 | ALOX5AP (0.57) | ALOX5APGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |