Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 5/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.54 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588716 | 1.00 | CHRNA3 (0.59) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL8437928 | 0.93 | CHRNB2 (0.61) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL8435310 | 0.93 | CHRNB2 (0.61) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL7407720 | 0.87 | CHRNB2 (0.53) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1 | |
| SCHEMBL18291358 | 0.86 | ALOX5AP (0.50) | CHRNA3GPR119ALOX5APFEN1 | |
| SCHEMBL7472930 | 0.86 | CHRNB2 (0.54) | CHRNA3CHRNB2CHRNA4GPR119ALOX5AP | |
| SCHEMBL7479360 | 0.86 | CHRNB2 (0.46) | CHRNA3CHRNB2CHRNA4GPR119ALOX5AP | |
| SCHEMBL7455050 | 0.85 | GPR119 (0.42) | CHRNA3GPR119ALOX5APFEN1 | |
| SCHEMBL7408557 | 0.85 | GPR119 (0.48) | CHRNA3GPR119ALOX5APFEN1 | |
| SCHEMBL7481577 | 0.84 | ALOX5AP (0.44) | CHRNA3GPR119ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128606-A1 | ANTIPRURITIC AGENT | TORAY INDUSTRIES, INC. (JP) | 2014-05-08 | — | — | US | disclosed |
| US-20140128606-A1 | ANTIPRURITIC AGENT | TORAY INDUSTRIES, INC. (JP) | 2014-05-08 | — | — | US | disclosed |
| US-20140128606-A1 | ANTIPRURITIC AGENT | TORAY INDUSTRIES, INC. (JP) | 2014-05-08 | — | — | US | disclosed |
| EP-2727604-A1 | ANTIPRURITIC AGENT | Toray Industries, Inc. (JP) | 2014-05-07 | — | — | EP | disclosed |
| EP-2727604-A1 | ANTIPRURITIC AGENT | Toray Industries, Inc. (JP) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013002365-A1 | ANTIPRURITIC AGENT | 東レ株式会社 (JP) | 2013-01-03 | — | — | WO | disclosed |
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| CN-1245496-A | 3-pyridyl enantiomers and their use as analgesics | ABBOTT LAB (US) | 2000-02-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128606-A1 | ANTIPRURITIC AGENT | MRGPRX2, HRH4, TRPV1 | CHRNA3 59/4885CHRNB2 61/4885CHRNA4 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.