SCHEMBL8435728

SCHEMBL8435728

CC(=O)N(C)[Si](c1ccccc1)(N(C)C(C)=O)N(C)C(C)=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
MAPT P10636 3/20 0.41
OPRM1 P35372 1/20 0.39
OPRL1 P41146 1/20 0.39
TSPO P30536 1/20 0.37
KMT2A Q03164 4/20 0.37
MEN1 O00255 1/20 0.37
HTT P42858 1/20 0.37
ELANE P08246 1/20 0.37
ALDH1A1 P00352 1/20 0.36
GLA P06280 1/20 0.36
TSHR P16473 1/20 0.36
NAPRT Q6XQN6 1/20 0.35
HSD17B10 Q99714 1/20 0.35
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ESR1 P03372 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9341835 0.83 CES2 (0.41) CES2CES1MAPTOPRM1OPRL1
SCHEMBL11544966 0.83 CES2 (0.41) CES2CES1MAPTOPRM1OPRL1
SCHEMBL9148153 0.81 MAPT (0.42) CES2CES1MAPTOPRM1OPRL1
SCHEMBL11516708 0.81 MAPT (0.42) CES2CES1MAPTOPRM1OPRL1
SCHEMBL765973 0.71 MEN1 (0.40) MAPTOPRM1OPRL1KMT2AMEN1
SCHEMBL1130961 0.67 CES2 (0.48) CES2CES1MAPTALDH1A1GLA
SCHEMBL14760071 0.67 CES2 (0.48) CES2CES1MAPTALDH1A1GLA
SCHEMBL14760301 0.67 CES2 (0.48) CES2CES1MAPTALDH1A1GLA
SCHEMBL11324533 0.67 MEN1 (0.43) MAPTKMT2AMEN1HTTALDH1A1
SCHEMBL11408419 0.67 ALDH1A1 (0.41) CES2CES1MAPTOPRM1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112375096-B Synthesis method of amido silane 江西晨光新材料股份有限公司 2023-05-02 CN disclosed
US-6008290-A A ROOM TEMPERATURE-CURABLE ORGANOPOLYSILOXANE HAVING HYDROXYL OR HYDROLYZABLE END GROUPS, A MONO-, DI- OR TRIKETOXIMESILANE AND A TETRAKETOXIMESILANE AND A TRIAZOLE-CONTAINING COMPOUND, E.G. TEBUCONAZOLE; ADHESIVES; SEALS; DISCOLORATION INHIBITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0562878-B1 Room temperature curable organopolysiloxane composition and cured product of the same SHINETSU CHEMICAL CO (JP) 1997-05-14 EP disclosed
US-5314981-A Fluoropolymer SHIN-ETSU CHEMICAL CO., LTD. (JP) 1994-05-24 US disclosed
EP-0562878-A2 Room temperature curable organopolysiloxane composition and cured product of the same SHIN-ETSU CHEMICAL CO., LTD. (JP) 1993-09-29 EP disclosed
US-5130401-A A polysiloxane, a filler, an organosilicon compound, a curing agent and a silane compound with amine and ester groups SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-07-14 US disclosed
US-4618646-A Room temperature-curable organopolysiloxane composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1986-10-21 US disclosed
US-4302571-A TERMINATED AT BOTH ENDS WITH SILANOIC HYDROXY GROUPS AND AN ORGANOSILANE OR ORGANOPOLYSILOXANE WITH HYDROLYZABLE GROUPS TO SERVE AS CROSSLINKING AGENTS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1981-11-24 US disclosed