Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439794 | 0.87 | ALDH1A1 (0.38) | ALDH1A1HPGDHSD17B10MRGPRX4HSD11B1 | |
| SCHEMBL8442180 | 0.85 | MEN1 (0.44) | HPGD | |
| SCHEMBL8442624 | 0.85 | MCL1 (0.45) | SLC9A1 | |
| SCHEMBL8443413 | 0.83 | SLC9A1 (0.62) | SLC9A1 | |
| SCHEMBL8441138 | 0.82 | CASP1 (0.45) | ALDH1A1 | |
| SCHEMBL8059436 | 0.81 | NR1H4 (0.46) | — | |
| SCHEMBL8438984 | 0.81 | TTR (0.51) | ALDH1A1HPGDMRGPRX4 | |
| SCHEMBL8441934 | 0.81 | BRD4 (0.47) | — | |
| SCHEMBL8442155 | 0.80 | HTT (0.56) | ALDH1A1HPGD | |
| SCHEMBL8442829 | 0.80 | MEN1 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708088-B1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0708088-A1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1996-04-24 | — | — | EP | disclosed |