Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443671 | 0.85 | FAAH (0.38) | L3MBTL1ALDH1A1 | |
| SCHEMBL27478242 | 0.85 | FAAH (0.38) | L3MBTL1ALDH1A1 | |
| SCHEMBL8443365 | 0.80 | LMNA (0.41) | LMNAPPARGPPARAMDM2ALDH1A1 | |
| SCHEMBL14339042 | 0.80 | MAPT (0.46) | LMNAL3MBTL1ALDH1A1PLAAT3PLAAT5 | |
| SCHEMBL9061912 | 0.79 | LMNA (0.40) | LMNAPPARGPPARAMDM2PLAAT3 | |
| SCHEMBL8552221 | 0.79 | MDM2 (0.44) | TDP1L3MBTL1MDM2ALDH1A1PKM | |
| SCHEMBL8772537 | 0.78 | POLB (0.40) | LMNATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8554773 | 0.78 | ALDH1A1 (0.54) | LMNATDP1L3MBTL1ALDH1A1PKM | |
| SCHEMBL8551199 | 0.77 | ALDH1A1 (0.43) | TDP1L3MBTL1ALDH1A1PKM | |
| SCHEMBL8438842 | 0.75 | PLAAT3 (0.47) | LMNAL3MBTL1ALDH1A1PLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |