SCHEMBL8438633

SCHEMBL8438633

O=C(Cl)c1ccc(CCBr)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.44
THRB P10828 3/20 0.42
THRA P10827 2/20 0.42
ALDH1A1 P00352 2/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
GSK3B P49841 1/20 0.38
HDAC1 Q13547 1/20 0.37
PLK1 P53350 1/20 0.37
POLB P06746 2/20 0.37
CTDSP1 Q9GZU7 2/20 0.37
KDM4E B2RXH2 1/20 0.37
GAA P10253 1/20 0.37
HSD17B10 Q99714 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6139457 0.88 THRA (0.47) THRBTHRAALDH1A1KMT2AMEN1
SCHEMBL7132233 0.86 HDAC1 (0.47) THRBTHRAALDH1A1KMT2ACA1
SCHEMBL526411 0.82 CES2 (0.57) TDP1THRBALDH1A1KMT2AMEN1
SCHEMBL27961330 0.82 TDP1 (0.48) TDP1THRBTHRAALDH1A1KMT2A
SCHEMBL11612824 0.82 TDP1 (0.48) TDP1THRBTHRAALDH1A1KMT2A
SCHEMBL83677 0.80 ALDH1A1 (0.56) TDP1THRBALDH1A1KMT2AMEN1
SCHEMBL3962189 0.80 CA1 (0.43) THRBTHRAALDH1A1KMT2ACA1
SCHEMBL1561636 0.79 THRA (0.44) THRBTHRAALDH1A1KMT2AMEN1
SCHEMBL8772450 0.78 ALDH1A1 (0.53) ALDH1A1KMT2AMEN1CES2CES1
SCHEMBL1019681 0.78 PLK1 (0.60) TDP1THRBTHRAALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105237660-A Polymer with stable nitroxide free radical as terminal group, and preparation method thereof UNIV FUDAN 2016-01-13 CN claimed
EP-4486453-A1 BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS F. Hoffmann-La Roche AG (CH) 2025-01-08 EP disclosed
CN-118843616-A Benzamide compounds for the treatment of bacterial infections 豪夫迈·罗氏有限公司 2024-10-25 CN disclosed
WO-2023166103-A1 BENZAMIDE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS F. HOFFMANN-LA ROCHE AG (CH) 2023-09-07 WO disclosed
CN-105237660-A Polymer with stable nitroxide free radical as terminal group, and preparation method thereof UNIV FUDAN 2016-01-13 CN disclosed
CN-102174191-A Application of linker of polyethylene glycol and fat-soluble compounds in biological catalysis UNIV TIANJIN SCIENCE & TECH 2011-09-07 CN disclosed
CN-101001887-A Multi-branched polymer and method for producing same NIPPON SODA CO (JP) 2007-07-18 CN disclosed
CN-1646508-A 5-substituted 1, 1-dioxo-1, 2, 5-thiadiazolidin-3-one derivatives as PTP-1B inhibitors NOVARTIS AG (CH) 2005-07-27 CN disclosed
US-5874194-A COPOLYMERIZED COMONOMER IS SELECTED FROM (METH)ACRYLIC ESTER, ACRYLIC ACID, ACRYLONITRILE, ALKYL ACRYLATE OR METHACRYLATE, ALKYL VINYL ETHER, VINYL ESTER, STYRENES, METHACRYLIC ACID, VINYL AMIDE, VINYL HALIDE, MALEIC ANHYDRIDE, METHACRYLAMIDE EASTMAN KODAK COMPANY (US) 1999-02-23 US disclosed
US-4752649-A IMPROVED RELATIVE THERMAL STABILITY AND EFFICIENT PHOTODECOMPOSITION BOWLING GREEN STATE UNIVERSITY (US) 1988-06-21 US disclosed
US-4478992-A PHOTOGRAPHY EASTMAN KODAK COMPANY (US) 1984-10-23 US disclosed
US-4420630-A BINDERS FOR PHOTOGRAPHY EASTMAN KODAK COMPANY (US) 1983-12-13 US disclosed