Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442775 | 0.87 | MEN1 (0.49) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7302254 | 0.83 | TDP1 (0.46) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL8830341 | 0.83 | MAPT (0.40) | MAPTTDP1POLBPSMB1PSMB8 | |
| SCHEMBL8830323 | 0.82 | MEN1 (0.47) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7307254 | 0.82 | MMP1 (0.49) | MAPTTDP1POLBRENKLK5 | |
| SCHEMBL9223666 | 0.82 | REN (0.49) | MAPTTDP1RENKLK5 | |
| Iodide SCHEMBL8830319 | 0.82 | MEN1 (0.47) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL7307169 | 0.82 | CCKBR (0.44) | MEN1KMT2AMAPTTDP1POLB | |
| SCHEMBL9339365 | 0.77 | MAPT (0.45) | MEN1KMT2AMAPTTDP1POLB | |
| SCHEMBL25336411 | 0.76 | MAPT (0.52) | MEN1ALDH1A1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384362-B1 | Glycinderivatives | HOFFMANN LA ROCHE (CH) | 1999-12-15 | — | — | EP | disclosed |
| US-5663297-A | OLIGOPEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0384362-A2 | Glycinderivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |