Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307169 | 0.92 | CCKBR (0.44) | TDP1MAPTCCKBRPOLBREN | |
| SCHEMBL7296817 | 0.92 | MAPT (0.44) | TDP1MAPTCCKBRPOLBREN | |
| Iodide SCHEMBL9221941 | 0.91 | CCKBR (0.43) | TDP1MAPTCCKBRPOLBREN | |
| SCHEMBL7301659 | 0.88 | CTSG (0.46) | TDP1MAPT | |
| SCHEMBL7307254 | 0.87 | MMP1 (0.49) | TDP1MAPTPOLBRENACE | |
| Iodide SCHEMBL9223883 | 0.87 | CCKBR (0.43) | TDP1MAPTCCKBRPOLBACE | |
| SCHEMBL8438729 | 0.83 | MEN1 (0.47) | TDP1MAPTPOLBRENKLK5 | |
| Iodide SCHEMBL9217545 | 0.83 | CCKBR (0.42) | TDP1MAPTCCKBRRENACE | |
| SCHEMBL7304175 | 0.83 | ITGB3 (0.43) | CCKBRMMP1 | |
| SCHEMBL9223666 | 0.82 | REN (0.49) | TDP1MAPTRENKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |