Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441616 | 0.97 | MAPT (0.60) | MAPTTDP1HPGDTSHRRAB9A | |
| Potassium Ion SCHEMBL1890648 | 0.92 | MAPT (0.67) | MAPTTDP1HPGDTSHRRAB9A | |
| SCHEMBL5311708 | 0.89 | MAPT (0.67) | MAPTTDP1HPGDTSHRRAB9A | |
| Potassium Ion SCHEMBL8441216 | 0.84 | KDM4E (0.62) | MAPTHPGDTSHRRAB9ANPC1 | |
| SCHEMBL1496045 | 0.83 | TDP1 (0.70) | MAPTTDP1HPGDTSHRRAB9A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL29385304 | 0.83 | TDP1 (0.70) | MAPTTDP1HPGDTSHRRAB9A | |
| SCHEMBL6704328 | 0.83 | MAPT (0.63) | MAPTTDP1HPGDTSHRRAB9A | |
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL166226 | 0.83 | TDP1 (0.70) | MAPTTDP1HPGDTSHRRAB9A | |
| Ammonia Solution, Strong SCHEMBL8439387 | 0.82 | TDP1 (0.68) | MAPTTDP1HPGDTSHRRAB9A | |
| SCHEMBL27816665 | 0.82 | MAPT (0.61) | MAPTTDP1HPGDTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939584-A | Process for preparing solid, free-flowing water-soluble salts of aryloxy-C1 -C4 -alkanecarboxylic acids | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-17 | — | — | US | disclosed |