Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 10/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257239 | 0.81 | CRBN (0.51) | CRBNDDB1TDP1GAACREBBP | |
| SCHEMBL17276659 | 0.81 | MEN1 (0.37) | CRBNDDB1GSK3BGAA | |
| SCHEMBL17276250 | 0.80 | DDB1 (0.55) | CRBNDDB1 | |
| SCHEMBL17276561 | 0.80 | DDB1 (0.55) | CRBNDDB1CREBBP | |
| SCHEMBL8522217 | 0.80 | CRBN (0.47) | CRBNDDB1GAACREBBP | |
| SCHEMBL8439360 | 0.80 | CRBN (0.47) | CRBNDDB1GAACREBBP | |
| SCHEMBL11036165 | 0.80 | CRBN (0.47) | CRBNDDB1GAACREBBP | |
| SCHEMBL17276398 | 0.79 | ALDH1A1 (0.36) | CRBNDDB1GAACREBBP | |
| SCHEMBL9253852 | 0.77 | CREBBP (0.44) | CRBNDDB1TP53MAPK1LMNA | |
| SCHEMBL8442975 | 0.77 | CRBN (0.55) | CRBNDDB1GAACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179293-A1 | SMALL MOLECULE ACTIVATORS AND INHIBITORS OF LECITHIN: CHOLESTEROL ACYLTRANSFERASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-11-26 | — | — | WO | claimed |
| WO-1995002579-A1 | SUBSTITUTED AZETIDINONE AMIDE DERIVATIVES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | ZENECA LIMITED (GB) | 1995-01-26 | — | — | WO | disclosed |