Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.65 |
| ▸ | NOS1 | P29475 | 2/20 | 0.65 |
| ▸ | NOS2 | P35228 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464203 | 0.82 | NOS1 (0.54) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| SCHEMBL2075410 | 0.79 | NOS3 (1.00) | NOS3NOS1NOS2SIGMAR1CTSD | |
| SCHEMBL3626217 | 0.79 | NOS3 (0.52) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| Hydrochloric Acid SCHEMBL8324907 | 0.77 | NOS3 (0.96) | NOS3NOS1NOS2SIGMAR1CTSD | |
| SCHEMBL3616940 | 0.76 | NOS3 (0.48) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| SCHEMBL35438 | 0.76 | NOS3 (0.48) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| SCHEMBL22983115 | 0.76 | NOS3 (0.77) | NOS3NOS1NOS2SIGMAR1CTSD | |
| SCHEMBL5021700 | 0.75 | NOS3 (0.46) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| SCHEMBL4465676 | 0.74 | NOS3 (0.47) | NOS3NOS1NOS2SIGMAR1TRPA1 | |
| SCHEMBL5830588 | 0.74 | NOS3 (0.42) | NOS3NOS1NOS2SIGMAR1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203745-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2009-08-13 | — | — | US | claimed |
| US-20090104116-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2009-04-23 | — | — | US | claimed |
| EP-2024357-A2 | NEW HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | Jereni AG (DE) | 2009-02-18 | — | — | EP | claimed |
| EP-1979342-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | Jerini AG (DE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007131764-A2 | NEW HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-11-22 | — | — | WO | claimed |
| WO-2007088041-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-08-09 | — | — | WO | claimed |
| JP-55079366-A | — | — | None | — | — | JP | disclosed |
| JP-55079365-A | — | — | None | — | — | JP | disclosed |
| JP-55133346-A | — | — | None | — | — | JP | disclosed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11773320-B2 | Organic electroluminescent materials and devices | UNIVERSAL DISPLAY CORPORATION (US) | 2023-10-03 | — | — | US | disclosed |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| WO-2023155855-A1 | APPLICATION OF 2-AMINO-3-INDOLE BUTYRIC ACID IN PROMOTING PLANT GROWTH | 南京天秾生物技术有限公司 | 2023-08-24 | — | — | WO | disclosed |
| WO-2007131764-A2 | NEW HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-11-22 | — | — | WO | disclosed |
| US-20070232604-A1 | receptor kinase inhibitors such as 3-(2-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-phenyl}-benzo[d]imidazo[2,1-b]thiazol-7-yl)-N-(2-morpholin-4-yl-ethyl)-propionamide; flk inhibitors | AMBIT BIOSCIENCES CORPORATION | 2007-10-04 | — | — | US | disclosed |
| WO-2007088041-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | JERINI AG (DE) | 2007-08-09 | — | — | WO | disclosed |
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. | 2007-07-26 | — | — | US | disclosed |
| JP-S55133346-A | PREPARATION OF LABELED PEPTIDE | ASAHI CHEM IND CO LTD | 1980-10-17 | — | — | JP | disclosed |
| JP-S5579365-A | PREPARATION OF INDOLE COMPOUND | ASAHI CHEM IND CO LTD | 1980-06-14 | — | — | JP | disclosed |
| JP-S5579366-A | PREPARATION OF 2-AMINOINDOLENINE | ASAHI CHEM IND CO LTD | 1980-06-14 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203745-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | ITGB1, ITGA2, ITGB2 | NOS3 2704/4885NOS1 2977/4885NOS2 2738/4885 |
| US-11773320-B2 | Organic electroluminescent materials and devices | CCNL2, HCN4, HNRNPL | NOS3 742/4885NOS1 1645/4885NOS2 1171/4885 |
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | NOS3 4318/4885NOS1 4432/4885NOS2 4429/4885 |
| US-20070232604-A1 | receptor kinase inhibitors such as 3-(2-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-phenyl}-benzo[d]imidazo[2,1-b]thiazol-7-yl)-N-(2-morpholin-4-yl-ethyl)-propionamide; flk inhibitors | GRK2, GRK3, BLK | NOS3 2737/4885NOS1 3668/4885NOS2 3170/4885 |
| US-20090104116-A1 | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF | ITGA1, ITGB1, ITGA5 | NOS3 2341/4885NOS1 1468/4885NOS2 2030/4885 |
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | NOS3 2808/4885NOS1 3559/4885NOS2 3203/4885 |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, CHUK, TGFBR1 | NOS3 1246/4885NOS1 917/4885NOS2 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.