Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439461 | 0.81 | ALDH1A1 (0.34) | CHRM5CHKANPC1L3MBTL1HSP90AA1 | |
| SCHEMBL8442576 | 0.79 | NSD2 (0.36) | NPC1L3MBTL1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL8439457 | 0.79 | SLC6A2 (0.35) | — | |
| SCHEMBL8039461 | 0.78 | MAPT (0.39) | CHRM5CHKAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL8439939 | 0.77 | SLC6A2 (0.35) | L3MBTL1HSP90AA1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8039050 | 0.77 | MAPT (0.38) | CHRM5CHKAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL9004605 | 0.76 | IRAK4 (0.33) | NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E | |
| SCHEMBL8435363 | 0.76 | CHKA (0.36) | CHRM5CHKANPC1L3MBTL1HSP90AA1 | |
| SCHEMBL8440253 | 0.72 | CHRM5 (0.38) | CHRM5CHKANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8440409 | 0.72 | CYP2A6 (0.43) | CHRM5CHKANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856335-A | GLYCINE PARTIAL AGONISTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5519032-A | ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0581106-A1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5252581-A | Modulators of neurotransmitters | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |