Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550015 | 0.91 | ACE (0.38) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8552490 | 0.91 | ALDH1A1 (0.42) | ACEALDH1A1POLBCYP2C9NPC1 | |
| SCHEMBL8551199 | 0.88 | ALDH1A1 (0.43) | L3MBTL1ACEALDH1A1POLBCYP2C9 | |
| SCHEMBL8557133 | 0.86 | ACE (0.37) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8551020 | 0.85 | ACE (0.43) | L3MBTL1ACEALDH1A1CYP1A2POLB | |
| SCHEMBL8552273 | 0.83 | ACE (0.37) | ACEALDH1A1NPC1RAB9A | |
| SCHEMBL8552221 | 0.81 | MDM2 (0.44) | L3MBTL1ACEALDH1A1POLBCYP2C9 | |
| SCHEMBL27484036 | 0.81 | ACE (0.40) | L3MBTL1ACEALDH1A1 | |
| SCHEMBL8554773 | 0.79 | ALDH1A1 (0.54) | L3MBTL1ACEALDH1A1POLBCYP2C9 | |
| SCHEMBL8440266 | 0.77 | ACE (0.46) | ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1197452-A | Azetidinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |