Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440266 | 0.87 | ACE (0.46) | ACESLC1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8557349 | 0.85 | L3MBTL1 (0.40) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8552490 | 0.85 | ALDH1A1 (0.42) | ACEALDH1A1POLBCYP2C9MEN1 | |
| SCHEMBL27484036 | 0.85 | ACE (0.40) | ACEALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8550015 | 0.83 | ACE (0.38) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8552407 | 0.83 | SLC1A2 (0.58) | ACESLC1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL8557133 | 0.82 | ACE (0.37) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8652713 | 0.81 | EPHX1 (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27486422 | 0.79 | MAPT (0.40) | ACEALDH1A1MAPT | |
| SCHEMBL8552273 | 0.78 | ACE (0.37) | ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |