Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440266 | 0.82 | ACE (0.46) | ACEALDH1A1SMN1; SMN2 | |
| SCHEMBL8551020 | 0.78 | ACE (0.43) | ACEL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8552407 | 0.76 | SLC1A2 (0.58) | ACEALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8551199 | 0.72 | ALDH1A1 (0.43) | ACETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8554773 | 0.71 | ALDH1A1 (0.54) | ACETDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27478642 | 0.71 | ACE (0.38) | CHRM2CHRM1CHRM3ACEALDH1A1 | |
| SCHEMBL8552221 | 0.71 | MDM2 (0.44) | ACETDP1L3MBTL1ALDH1A1 | |
| SCHEMBL12658891 | 0.70 | LTB4R2 (0.68) | ATMLTB4R2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8557349 | 0.69 | L3MBTL1 (0.40) | ACEL3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL8552490 | 0.69 | ALDH1A1 (0.42) | ACEALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |