Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 7/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414836 | 0.74 | L3MBTL1 (0.61) | L3MBTL1CA2CA1CA12CA9 | |
| SCHEMBL6152466 | 0.71 | EDNRA (0.48) | — | |
| SCHEMBL7768529 | 0.68 | CA2 (0.44) | CA2CA1CA12CA9ALDH1A1 | |
| SCHEMBL6798951 | 0.67 | ACLY (0.44) | L3MBTL1CA2CA1CA12CA9 | |
| SCHEMBL22379192 | 0.66 | MAP3K9 (0.40) | PDE3BPDE3ASLC9A1SLC22A12CA2 | |
| SCHEMBL7343886 | 0.64 | CNR2 (0.43) | L3MBTL1SLC9A1CA2CA1CA12 | |
| SCHEMBL21692687 | 0.64 | GPR3 (0.38) | PDE3BPDE3ASLC9A1SLC22A12CA2 | |
| SCHEMBL21691826 | 0.64 | PARP14 (0.45) | SLC9A1SLC22A12CA2CA1ESR2 | |
| SCHEMBL9842740 | 0.63 | TSHR (0.34) | SLC22A12ESR2ALDH1A1HTT | |
| SCHEMBL21693065 | 0.63 | ALOX5 (0.54) | SLC9A1SLC22A12CA2CA1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946552-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998013366-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-04-02 | — | — | WO | disclosed |