SCHEMBL8445443

SCHEMBL8445443

COC(=O)c1ccc(C(F)(F)F)nc1SCc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
ALDH1A1 P00352 4/20 0.52
TDP1 Q9NUW8 1/20 0.52
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44
TUBB2B Q9BVA1 1/20 0.44
TUBB1 Q9H4B7 1/20 0.44
PTGS2 P35354 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9710155 0.86 ALDH1A1 (0.56) PKML3MBTL1ALDH1A1PTGS2PPARG
SCHEMBL13018084 0.78 PLA2G2A (0.47) PKML3MBTL1TUBB4ATUBBTUBA3C
SCHEMBL21199820 0.76 PKM (0.49) PKML3MBTL1ALDH1A1TDP1PTGS2
SCHEMBL8630241 0.76 L3MBTL1 (1.00) PKML3MBTL1ALDH1A1TDP1CYP2C9
SCHEMBL10464789 0.74 L3MBTL1 (0.55) PKML3MBTL1ALDH1A1TDP1METAP2
SCHEMBL13853225 0.74 TUBB4A (0.49) ALDH1A1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL9565846 0.73 TUBB4A (0.52) ALDH1A1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL31568285 0.73 ALDH1A1 (0.64) PKML3MBTL1ALDH1A1TDP1PPARG
SCHEMBL3878179 0.72 TUBB4A (0.56) L3MBTL1ALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL16346551 0.72 KDM4E (0.44) L3MBTL1ALDH1A1NPC1RAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0575503-B1 HERBICIDAL PYRIDINE SULFONAMIDE DU PONT (US) 1999-11-24 EP disclosed
EP-0502740-B1 Herbicidal pyridine sulfonamide DU PONT (US) 1998-05-27 EP disclosed
US-5393734-A Herbicidal pyridine sulfonamide E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-02-28 US disclosed
EP-0575503-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-12-29 EP disclosed
WO-1992015576-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-17 WO disclosed